Assay Detail
Binding
CHEMBL3395876
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Inhibition of PI3K p110beta (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.73 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3188551 | GSK-2636771 | 2.0 | 1 | 9.05 |
| CHEMBL589258 | — | — | 1 | 8.15 |
| CHEMBL1921986 | — | — | 1 | 7.57 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.36 |
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 7.17 |
| CHEMBL1972466 | — | — | 1 | 5.70 |
| CHEMBL478980 | — | — | 1 | 5.43 |
| CHEMBL3218573 | — | — | 1 | 5.30 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3188551 | GSK-2636771 | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL589258 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1921986 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3393066 | VS-5584 | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1972466 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL478980 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3218573 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL98350 | LY-294002 | IC50 | = | 16000.0 | nM | 4.80 |