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Assay Detail

CHEMBL3396028

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to cyclin A2 (174 to 432) (unknown origin) by fluorescence polarization assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cyclin-A2 (CHEMBL2582)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity.
Premnath PN, Craig SN, Liu S, Anderson EL, Grigoroudis AI, Kontopidis G, Perkins TL, Wyatt MD, Pittman DL, McInnes C.
J Med Chem (2015) 58 : 433 -442
PubMed 25454794 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 7.72 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3393766 1 7.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3393766 Kd = 19.0 nM 7.72