Assay Detail
Binding
CHEMBL3396041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.78 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129159 | — | — | 1 | 8.70 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.60 |
| CHEMBL129237 | — | — | 1 | 8.52 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.15 |
| CHEMBL3393789 | — | — | 1 | 7.06 |
| CHEMBL3393790 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129159 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL129237 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 70.1 | nM | 7.15 |
| CHEMBL3393789 | — | Ki | = | 87.5 | nM | 7.06 |
| CHEMBL3393790 | — | Ki | = | 230.0 | nM | 6.64 |