Assay Detail
Functional
CHEMBL3396058
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Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated reporter gene activity
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diaminopyrimidines, diaminopyridines and diaminopyridazines as histamine H4 receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.90 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393542 | — | — | 1 | 8.40 |
| CHEMBL3393539 | — | — | 1 | 7.82 |
| CHEMBL3393546 | — | — | 1 | 7.70 |
| CHEMBL3354815 | — | — | 1 | 7.60 |
| CHEMBL3393529 | — | — | 1 | 7.32 |
| CHEMBL3393543 | — | — | 1 | 7.12 |
| CHEMBL3393538 | — | — | 1 | 7.08 |
| CHEMBL3393544 | — | — | 1 | 7.07 |
| CHEMBL3393541 | — | — | 1 | 7.04 |
| CHEMBL3393536 | — | — | 1 | 6.95 |
| CHEMBL3393556 | — | — | 1 | 6.00 |
| CHEMBL3354816 | — | — | 1 | 5.50 |
| CHEMBL3393550 | — | — | 1 | 5.50 |
| CHEMBL3393547 | — | — | 1 | 5.50 |
| CHEMBL3393535 | — | — | 1 | - |
| CHEMBL3393534 | — | — | 1 | - |
| CHEMBL3393548 | — | — | 1 | - |
| CHEMBL3393533 | — | — | 1 | - |
| CHEMBL3393532 | — | — | 1 | - |
| CHEMBL3393557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393542 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3393539 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3393546 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3354815 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3393529 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3393543 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3393538 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3393544 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3393541 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3393536 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3393556 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3354816 | — | EC50 | = | 3162.0 | nM | 5.50 |
| CHEMBL3393550 | — | EC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL3393547 | — | EC50 | = | 3162.0 | nM | 5.50 |
| CHEMBL3393535 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3393534 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3393548 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3393533 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3393532 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3393557 | — | EC50 | > | 10000.0 | nM | - |