Compound Detail
CHEMBL3393542
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Basic Information
| ChEMBL ID | CHEMBL3393542 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FMAHIXYZGXPWMZ-LLVKDONJSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
249.4
MW (Da)
1.49
ALogP
5
HBA
2
HBD
53.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.7
EC50 1 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H4 receptor CHEMBL3759 | Ki | 8.7 | 8.61 | 2.0 | 2 |
| Histamine H4 receptor CHEMBL3759 | EC50 | 8.4 | 8.4 | 4.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H4 receptor | Ki | = | 2.0 | nM | 8.7 | Binding Assay: Cell pellets from SK-N-MC cells stably or transiently transfected... | - |
| Histamine H4 receptor | Ki | = | 3.0 | nM | 8.52 | Displacement of [3H]histamine from human recombinant histamine H4 receptor | 25595684 |
| Histamine H4 receptor | EC50 | = | 4.0 | nM | 8.4 | Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC... | 25595684 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25595684 | 10.1016/j.bmcl.2014.12.027 | Histamine H4 receptor | 2 |
Data from ChEMBL 36 via Core Engine