Assay Detail
Binding
CHEMBL3396754
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Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of c-Jun N-terminal kinases: an update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.69 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393608 | — | — | 1 | 8.05 |
| CHEMBL3393607 | — | — | 1 | 6.61 |
| CHEMBL2216824 | — | — | 1 | 6.47 |
| CHEMBL3393606 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393608 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3393607 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL2216824 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL3393606 | — | IC50 | = | 2400.0 | nM | 5.62 |