Assay Detail
Functional
CHEMBL3396787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimelanogenic activity in mouse B16F10 cells assessed as inhibition of melanin production after 4 days
17
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.29 | 5.64 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393844 | — | — | 1 | 5.64 |
| CHEMBL3393849 | — | — | 1 | 5.60 |
| CHEMBL3393850 | — | — | 1 | 5.57 |
| CHEMBL570248 | — | — | 1 | 5.52 |
| CHEMBL406837 | — | — | 1 | 5.51 |
| CHEMBL3393846 | — | — | 1 | 5.47 |
| CHEMBL258497 | — | — | 1 | 5.42 |
| CHEMBL251958 | FLAVOKAWAIN C | — | 2 | 5.16 |
| CHEMBL104255 | FLAVOKAWAIN B | — | 2 | 5.11 |
| CHEMBL3393845 | — | — | 1 | 5.00 |
| CHEMBL3393848 | — | — | 1 | 5.00 |
| CHEMBL244042 | — | — | 1 | 4.50 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL243829 | FLAVOKAWAIN A | — | 1 | - |
| CHEMBL3393847 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393844 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3393849 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3393850 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL570248 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL406837 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3393846 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL258497 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL251958 | FLAVOKAWAIN C | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL104255 | FLAVOKAWAIN B | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3393848 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL3393845 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL244042 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL243829 | FLAVOKAWAIN A | IC50 | - | — | - | |
| CHEMBL3393847 | — | IC50 | - | — | - | |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 500000.0 | nM | - |
| CHEMBL104255 | FLAVOKAWAIN B | Inhibition | - | % | - | |
| CHEMBL251958 | FLAVOKAWAIN C | Inhibition | - | % | - |