Assay Detail
Binding
CHEMBL3398676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of wild-type human presenilin-1 stably overexpressed in CHO cells co-expressing wild-type human amyloid precursor protein assessed as amyloid beta 38 formation after 24 hrs by ELISA
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 5.41 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3397724 | — | — | 1 | 6.01 |
| CHEMBL3397717 | — | — | 1 | 6.00 |
| CHEMBL3397727 | — | — | 1 | 5.96 |
| CHEMBL1819479 | — | — | 1 | 5.96 |
| CHEMBL3397721 | — | — | 1 | 5.93 |
| CHEMBL3397728 | — | — | 1 | 5.89 |
| CHEMBL3397714 | — | — | 1 | 5.75 |
| CHEMBL3397719 | — | — | 1 | 5.68 |
| CHEMBL3397722 | — | — | 1 | 5.66 |
| CHEMBL3397711 | — | — | 1 | 5.60 |
| CHEMBL3397716 | — | — | 1 | 5.50 |
| CHEMBL3397713 | — | — | 1 | 5.50 |
| CHEMBL3397712 | — | — | 1 | 5.36 |
| CHEMBL3397723 | — | — | 1 | 5.35 |
| CHEMBL1171834 | — | — | 1 | 5.34 |
| CHEMBL3397720 | — | — | 1 | 4.97 |
| CHEMBL461883 | — | — | 1 | 4.95 |
| CHEMBL3397726 | — | — | 1 | 4.95 |
| CHEMBL3397708 | — | — | 1 | 4.92 |
| CHEMBL3397715 | — | — | 1 | 4.86 |
| CHEMBL3397710 | — | — | 1 | 4.85 |
| CHEMBL3397709 | — | — | 1 | 4.81 |
| CHEMBL3397718 | — | — | 1 | 4.63 |
| CHEMBL3397725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3397724 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3397717 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3397727 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1819479 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3397721 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL3397728 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3397714 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3397719 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3397722 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3397711 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3397716 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3397713 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3397712 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3397723 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1171834 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3397720 | — | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL461883 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3397726 | — | EC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3397708 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3397715 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3397710 | — | EC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3397709 | — | EC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3397718 | — | EC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL3397725 | — | EC50 | > | 40000.0 | nM | - |