Assay Detail
Functional
CHEMBL3398735
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Cytostatic activity against human HeLa cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.20 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574646 | — | — | 1 | 6.70 |
| CHEMBL3397753 | — | — | 1 | 6.16 |
| CHEMBL3397752 | — | — | 1 | 6.16 |
| CHEMBL3338598 | — | — | 1 | 6.10 |
| CHEMBL1629985 | — | — | 1 | 6.10 |
| CHEMBL3397751 | — | — | 1 | 6.05 |
| CHEMBL3397747 | — | — | 1 | 6.05 |
| CHEMBL3397749 | — | — | 1 | 5.66 |
| CHEMBL3397738 | — | — | 1 | 5.58 |
| CHEMBL154716 | — | — | 1 | 5.58 |
| CHEMBL3397746 | — | — | 1 | 5.58 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.57 |
| CHEMBL3397748 | — | — | 1 | 5.52 |
| CHEMBL3397737 | — | — | 1 | 5.41 |
| CHEMBL3397750 | — | — | 1 | 5.33 |
| CHEMBL3397739 | — | — | 1 | 5.32 |
| CHEMBL3397743 | — | — | 1 | 4.92 |
| CHEMBL3397755 | — | — | 1 | 4.82 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.75 |
| CHEMBL3397742 | — | — | 1 | 4.60 |
| CHEMBL3397745 | — | — | 1 | 4.58 |
| CHEMBL3397740 | — | — | 1 | 4.50 |
| CHEMBL3397759 | — | — | 1 | 4.15 |
| CHEMBL3397760 | — | — | 1 | 4.15 |
| CHEMBL3397762 | — | — | 1 | 4.13 |
| CHEMBL3397758 | — | — | 1 | 4.08 |
| CHEMBL3397757 | — | — | 1 | 4.02 |
| CHEMBL3397754 | — | — | 1 | 4.00 |
| CHEMBL3397756 | — | — | 1 | - |
| CHEMBL3397761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574646 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3397753 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3397752 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3338598 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1629985 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3397751 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3397747 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3397749 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3397738 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL154716 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3397746 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3397748 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3397737 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3397750 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3397739 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3397743 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3397755 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL140 | CURCUMIN | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3397742 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3397745 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3397740 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3397759 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL3397760 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL3397762 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL3397758 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL3397757 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL3397754 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3397756 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3397761 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3397741 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL3397744 | — | IC50 | > | 125000.0 | nM | - |