Assay Detail
Functional
CHEMBL3398943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Trypanocidal activity against drug-sensitive Trypanosoma brucei brucei Lab 110 EATRO assessed as inhibition of trypanosomes after 48 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.80 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378650 | — | — | 1 | 6.21 |
| CHEMBL3398186 | — | — | 1 | 5.86 |
| CHEMBL332939 | — | — | 1 | 5.78 |
| CHEMBL3398189 | — | — | 1 | 5.59 |
| CHEMBL3398187 | — | — | 1 | 5.55 |
| CHEMBL3398188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378650 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3398186 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL332939 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL3398189 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL3398187 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3398188 | — | IC50 | - | — | - |