Assay Detail
Functional
CHEMBL3398944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Trypanocidal activity against clinical isolate Trypanosoma brucei rhodesiense KETRI 243 assessed as inhibition of trypanosomes after 48 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.67 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398189 | — | — | 1 | 5.82 |
| CHEMBL3398187 | — | — | 1 | 5.80 |
| CHEMBL332939 | — | — | 1 | 5.70 |
| CHEMBL378650 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398189 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3398187 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL332939 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL378650 | — | IC50 | = | 4500.0 | nM | 5.35 |