Assay Detail
Functional
CHEMBL3398946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Trypanocidal activity against pentamidine and melarsoprol-resistant Trypanosoma brucei rhodesiense K 243-As-10-3 assessed as inhibition of trypanosomes after 48 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.05 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398187 | — | — | 1 | 5.40 |
| CHEMBL378650 | — | — | 1 | 5.08 |
| CHEMBL3398189 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398187 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL378650 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3398189 | — | IC50 | = | 22000.0 | nM | 4.66 |