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Assay Detail

CHEMBL3398981

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to basic fibroblast growth factor (unknown origin) using sugar chip immobilized compound by surface plasmon resonance method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor 2 (CHEMBL3107)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of a chondroitin sulfate disaccharide library and a GAG-binding protein interaction analysis.
Wakao M, Obata R, Miyachi K, Kaitsubata Y, Kondo T, Sakami C, Suda Y.
Bioorg Med Chem Lett (2015) 25 : 1407 -1411
PubMed 25765912 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 16 7.42 8.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3397498 1 8.31
CHEMBL3397488 1 7.80
CHEMBL3397494 1 7.68
CHEMBL3397491 1 7.64
CHEMBL3397487 1 7.60
CHEMBL3397485 1 7.44
CHEMBL3397490 1 7.39
CHEMBL3397489 1 7.39
CHEMBL3397496 1 7.28
CHEMBL3397495 1 7.22
CHEMBL3397486 1 7.21
CHEMBL3397493 1 7.02
CHEMBL3397497 1 7.00
CHEMBL3397492 1 6.83
CHEMBL3397484 1 -
CHEMBL3397483 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3397498 Kd = 4.9 nM 8.31
CHEMBL3397488 Kd = 16.0 nM 7.80
CHEMBL3397494 Kd = 21.0 nM 7.68
CHEMBL3397491 Kd = 23.0 nM 7.64
CHEMBL3397487 Kd = 25.0 nM 7.60
CHEMBL3397485 Kd = 36.0 nM 7.44
CHEMBL3397490 Kd = 41.0 nM 7.39
CHEMBL3397489 Kd = 41.0 nM 7.39
CHEMBL3397496 Kd = 52.0 nM 7.28
CHEMBL3397495 Kd = 60.0 nM 7.22
CHEMBL3397486 Kd = 62.0 nM 7.21
CHEMBL3397493 Kd = 95.0 nM 7.02
CHEMBL3397497 Kd = 99.0 nM 7.00
CHEMBL3397492 Kd = 147.0 nM 6.83
CHEMBL3397484 Kd - -
CHEMBL3397483 Kd - -