Assay Detail
Binding
CHEMBL3399152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by competition binding assays
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.14 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3397337 | — | — | 1 | 9.46 |
| CHEMBL3397339 | — | — | 1 | 9.42 |
| CHEMBL3397341 | — | — | 1 | 9.29 |
| CHEMBL3397336 | — | — | 1 | 8.96 |
| CHEMBL3397338 | — | — | 1 | 8.69 |
| CHEMBL3397340 | — | — | 1 | 8.56 |
| CHEMBL3397335 | — | — | 1 | 8.11 |
| CHEMBL3397342 | — | — | 1 | 8.00 |
| CHEMBL3397333 | — | — | 1 | 7.87 |
| CHEMBL3397334 | — | — | 1 | 7.79 |
| CHEMBL3397344 | — | — | 1 | 7.49 |
| CHEMBL3397343 | — | — | 1 | 7.44 |
| CHEMBL3397345 | — | — | 1 | 7.33 |
| CHEMBL3397346 | — | — | 1 | 7.05 |
| CHEMBL3397347 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3397337 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL3397339 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL3397341 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL3397336 | — | Ki | = | 1.09 | nM | 8.96 |
| CHEMBL3397338 | — | Ki | = | 2.05 | nM | 8.69 |
| CHEMBL3397340 | — | Ki | = | 2.77 | nM | 8.56 |
| CHEMBL3397335 | — | Ki | = | 7.74 | nM | 8.11 |
| CHEMBL3397342 | — | Ki | = | 9.98 | nM | 8.00 |
| CHEMBL3397333 | — | Ki | = | 13.45 | nM | 7.87 |
| CHEMBL3397334 | — | Ki | = | 16.33 | nM | 7.79 |
| CHEMBL3397344 | — | Ki | = | 32.33 | nM | 7.49 |
| CHEMBL3397343 | — | Ki | = | 36.53 | nM | 7.44 |
| CHEMBL3397345 | — | Ki | = | 46.55 | nM | 7.33 |
| CHEMBL3397346 | — | Ki | = | 89.89 | nM | 7.05 |
| CHEMBL3397347 | — | Ki | = | 199.97 | nM | 6.70 |