Assay Detail
Functional
CHEMBL3399203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 ROD infected in human MT4 cells assessed as protection against virus-induced cytotoxicity after 5 days by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Design, synthesis of new β-carboline derivatives and their selective anti-HIV-2 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.78 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.80 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.64 |
| CHEMBL3398382 | — | — | 1 | 5.58 |
| CHEMBL3398377 | — | — | 1 | 5.50 |
| CHEMBL3398373 | — | — | 1 | 5.48 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.45 |
| CHEMBL3398383 | — | — | 1 | 5.27 |
| CHEMBL3398372 | — | — | 1 | 4.53 |
| CHEMBL3398375 | — | — | 1 | - |
| CHEMBL3398374 | — | — | 1 | - |
| CHEMBL3398378 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL3398387 | — | — | 1 | - |
| CHEMBL3398386 | — | — | 1 | - |
| CHEMBL3398385 | — | — | 1 | - |
| CHEMBL3398384 | — | — | 1 | - |
| CHEMBL3398379 | — | — | 1 | - |
| CHEMBL3398376 | — | — | 1 | - |
| CHEMBL3398381 | — | — | 1 | - |
| CHEMBL3398380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL3398382 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3398377 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3398373 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL3398383 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3398372 | — | EC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL3398375 | — | EC50 | > | 210000.0 | nM | - |
| CHEMBL3398374 | — | EC50 | > | 16900.0 | nM | - |
| CHEMBL3398378 | — | EC50 | > | 208300.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 4000.0 | nM | - |
| CHEMBL3398387 | — | EC50 | > | 19200.0 | nM | - |
| CHEMBL3398386 | — | EC50 | > | 4020.0 | nM | - |
| CHEMBL3398385 | — | EC50 | > | 21700.0 | nM | - |
| CHEMBL3398384 | — | EC50 | > | 63900.0 | nM | - |
| CHEMBL3398379 | — | EC50 | > | 110600.0 | nM | - |
| CHEMBL3398376 | — | EC50 | > | 133900.0 | nM | - |
| CHEMBL3398381 | — | EC50 | > | 203600.0 | nM | - |
| CHEMBL3398380 | — | EC50 | > | 23600.0 | nM | - |