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Assay Detail

CHEMBL3399253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bakers yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate after 30 mins by spectrophotometry
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Oligo-1,6-glucosidase IMA1 (CHEMBL5848)
Type SINGLE PROTEIN
Organism Saccharomyces cerevisiae S288c

Publication

Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitors.
Han K, Li Y, Zhang Y, Teng Y, Ma Y, Wang M, Wang R, Xu W, Yao Q, Zhang Y, Qin H, Sun H, Yu P.
Bioorg Med Chem Lett (2015) 25 : 1471 -1475
PubMed 25759031 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.56 5.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3397482 1 5.32
CHEMBL3397478 1 4.92
CHEMBL3397481 1 4.80
CHEMBL3397479 1 4.80
CHEMBL3397480 1 4.54
CHEMBL3397477 1 4.49
CHEMBL3397476 1 4.46
CHEMBL3397050 1 4.41
CHEMBL3397473 1 4.37
CHEMBL3397466 1 4.34
CHEMBL3397471 1 4.12
CHEMBL3397472 1 4.11
CHEMBL3397464 1 -
CHEMBL404271 ACARBOSE 4.0 1 -
CHEMBL3397465 1 -
CHEMBL3397467 1 -
CHEMBL3397468 1 -
CHEMBL3397469 1 -
CHEMBL3397470 1 -
CHEMBL3397474 1 -
CHEMBL3397475 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3397482 IC50 = 4800.0 nM 5.32
CHEMBL3397478 IC50 = 12100.0 nM 4.92
CHEMBL3397481 IC50 = 16000.0 nM 4.80
CHEMBL3397479 IC50 = 15700.0 nM 4.80
CHEMBL3397480 IC50 = 29000.0 nM 4.54
CHEMBL3397477 IC50 = 32300.0 nM 4.49
CHEMBL3397476 IC50 = 34800.0 nM 4.46
CHEMBL3397050 IC50 = 39300.0 nM 4.41
CHEMBL3397473 IC50 = 42900.0 nM 4.37
CHEMBL3397466 IC50 = 45300.0 nM 4.34
CHEMBL3397471 IC50 = 75900.0 nM 4.12
CHEMBL3397472 IC50 = 77100.0 nM 4.11
CHEMBL3397464 IC50 = 287200.0 nM -
CHEMBL404271 ACARBOSE IC50 = 115800.0 nM -
CHEMBL3397465 IC50 = 117300.0 nM -
CHEMBL3397467 IC50 = 187400.0 nM -
CHEMBL3397468 IC50 > 300000.0 nM -
CHEMBL3397469 IC50 = 111500.0 nM -
CHEMBL3397470 IC50 = 149900.0 nM -
CHEMBL3397474 IC50 > 300000.0 nM -
CHEMBL3397475 IC50 = 104700.0 nM -