Assay Detail
Binding
CHEMBL3399659
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Displacement of [3H]CP55,940 from human recombinant CB2 receptor expressed in HEK293 cell membranes after 90 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.50 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381689 | SR-144528 | — | 1 | 9.22 |
| CHEMBL371214 | — | — | 1 | 8.52 |
| CHEMBL3397520 | — | — | 1 | 7.94 |
| CHEMBL3397522 | — | — | 1 | 7.66 |
| CHEMBL3397517 | — | — | 1 | 7.22 |
| CHEMBL3397519 | — | — | 1 | 7.22 |
| CHEMBL3397449 | — | — | 1 | 7.05 |
| CHEMBL3397518 | — | — | 1 | 7.05 |
| CHEMBL3397448 | — | — | 1 | 7.00 |
| CHEMBL3397521 | — | — | 1 | 6.84 |
| CHEMBL3397450 | — | — | 1 | 6.82 |
| CHEMBL3397445 | — | — | 1 | - |
| CHEMBL3397446 | — | — | 1 | - |
| CHEMBL3397447 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381689 | SR-144528 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL371214 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3397520 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL3397522 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3397517 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3397519 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3397449 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3397518 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3397448 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3397521 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL3397450 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL3397445 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3397446 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3397447 | — | Ki | > | 10000.0 | nM | - |