Assay Detail
Functional
CHEMBL3399764
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Inhibition of superoxide generation in fMLF/CB-induced human neutrophils preincubated for 5 mins before fMLF/CB treatment by spectrophotometry
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.00 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398160 | — | — | 1 | 5.43 |
| CHEMBL3398149 | — | — | 1 | 4.87 |
| CHEMBL3398148 | — | — | 1 | 4.71 |
| CHEMBL3398144 | — | — | 1 | - |
| CHEMBL3398145 | — | — | 1 | - |
| CHEMBL3398146 | — | — | 1 | - |
| CHEMBL3398147 | — | — | 1 | - |
| CHEMBL3398150 | — | — | 1 | - |
| CHEMBL3398151 | — | — | 1 | - |
| CHEMBL3398152 | — | — | 1 | - |
| CHEMBL3398153 | — | — | 1 | - |
| CHEMBL3398154 | — | — | 1 | - |
| CHEMBL3398143 | — | — | 1 | - |
| CHEMBL3398156 | — | — | 1 | - |
| CHEMBL3398157 | — | — | 1 | - |
| CHEMBL3398158 | — | — | 1 | - |
| CHEMBL3398159 | — | — | 1 | - |
| CHEMBL3398161 | — | — | 1 | - |
| CHEMBL3398162 | — | — | 1 | - |
| CHEMBL3398163 | — | — | 1 | - |
| CHEMBL3398164 | — | — | 1 | - |
| CHEMBL3398165 | — | — | 1 | - |
| CHEMBL76688 | SIVELESTAT | 3.0 | 1 | - |
| CHEMBL3398155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398160 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL3398149 | — | IC50 | = | 13370.0 | nM | 4.87 |
| CHEMBL3398148 | — | IC50 | = | 19610.0 | nM | 4.71 |
| CHEMBL3398144 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398145 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398146 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398147 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398150 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398151 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398152 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398153 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398154 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398143 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398156 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398157 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398158 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398159 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398161 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398162 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398163 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398164 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398165 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL76688 | SIVELESTAT | IC50 | > | 20000.0 | nM | - |
| CHEMBL3398155 | — | IC50 | > | 20000.0 | nM | - |