Assay Detail
Binding
CHEMBL3399810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine pancreatic elastase using methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide as substrate preincubated for 15 mins before substrate addition measured after 60 mins by spectrophotometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.69 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398148 | — | — | 1 | 5.72 |
| CHEMBL76688 | SIVELESTAT | 3.0 | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398148 | — | IC50 | = | 1881.98 | nM | 5.72 |
| CHEMBL76688 | SIVELESTAT | IC50 | = | 2185.17 | nM | 5.66 |