Assay Detail
Binding
CHEMBL3399896
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Inhibition of human coagulation factor 11a at 25 degC
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.67 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398612 | — | — | 1 | 9.51 |
| CHEMBL3398615 | — | — | 1 | 8.99 |
| CHEMBL3398614 | — | — | 1 | 8.94 |
| CHEMBL3398644 | — | — | 1 | 8.92 |
| CHEMBL3398613 | — | — | 1 | 8.83 |
| CHEMBL3398636 | — | — | 1 | 8.82 |
| CHEMBL3398640 | — | — | 1 | 8.72 |
| CHEMBL3398616 | — | — | 3 | 8.67 |
| CHEMBL3398641 | — | — | 1 | 8.57 |
| CHEMBL3398639 | — | — | 1 | 8.47 |
| CHEMBL3398635 | — | — | 1 | 8.24 |
| CHEMBL3398642 | — | — | 1 | 8.17 |
| CHEMBL3398617 | — | — | 1 | 7.72 |
| CHEMBL3398634 | — | — | 1 | 7.64 |
| CHEMBL3398629 | — | — | 1 | 7.51 |
| CHEMBL3398638 | — | — | 1 | 7.34 |
| CHEMBL3398630 | — | — | 1 | 7.28 |
| CHEMBL3398628 | — | — | 1 | 7.27 |
| CHEMBL3398633 | — | — | 1 | 7.24 |
| CHEMBL3398618 | — | — | 1 | 7.24 |
| CHEMBL3398626 | — | — | 1 | 7.19 |
| CHEMBL3398621 | — | — | 1 | 7.17 |
| CHEMBL3398632 | — | — | 1 | 7.12 |
| CHEMBL3398619 | — | — | 1 | 6.90 |
| CHEMBL3398624 | — | — | 1 | 6.70 |
| CHEMBL3398631 | — | — | 1 | 6.62 |
| CHEMBL3398625 | — | — | 1 | 6.55 |
| CHEMBL3398622 | — | — | 1 | 6.51 |
| CHEMBL3398623 | — | — | 1 | 6.41 |
| CHEMBL3398637 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398612 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL3398615 | — | Ki | = | 1.03 | nM | 8.99 |
| CHEMBL3398614 | — | Ki | = | 1.16 | nM | 8.94 |
| CHEMBL3398644 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3398613 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL3398636 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3398640 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL3398616 | — | Ki | = | 2.15 | nM | 8.67 |
| CHEMBL3398616 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL3398616 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL3398641 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL3398639 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL3398635 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL3398642 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL3398617 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3398634 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3398629 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3398638 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL3398630 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL3398628 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL3398633 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL3398618 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL3398626 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL3398621 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL3398632 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL3398619 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL3398624 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3398631 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3398625 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL3398622 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3398623 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL3398637 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL3398627 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL3398620 | — | Ki | = | 2900.0 | nM | 5.54 |