Assay Detail
Functional
CHEMBL3404057
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Agonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.64 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403507 | — | — | 1 | 7.26 |
| CHEMBL3403508 | — | — | 1 | 6.02 |
| CHEMBL3403504 | — | — | 1 | - |
| CHEMBL3403505 | — | — | 1 | - |
| CHEMBL3403506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403507 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3403508 | — | EC50 | = | 951.0 | nM | 6.02 |
| CHEMBL3403504 | — | EC50 | - | — | - | |
| CHEMBL3403505 | — | EC50 | - | — | - | |
| CHEMBL3403506 | — | EC50 | - | — | - |