Assay Detail
Functional
CHEMBL3404064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A431 cells after 48 hrs by sulforhodamine B assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.54 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403510 | — | — | 1 | 8.01 |
| CHEMBL3403518 | — | — | 1 | 7.94 |
| CHEMBL3403509 | — | — | 1 | 7.77 |
| CHEMBL3403517 | — | — | 1 | 7.75 |
| CHEMBL3297898 | — | — | 1 | 7.68 |
| CHEMBL3403513 | — | — | 1 | 7.42 |
| CHEMBL3403515 | — | — | 1 | 7.38 |
| CHEMBL3403512 | — | — | 1 | 7.31 |
| CHEMBL3403514 | — | — | 1 | 7.13 |
| CHEMBL3403519 | — | — | 1 | 7.03 |
| CHEMBL3403511 | — | — | 1 | - |
| CHEMBL3403516 | — | — | 1 | - |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | - |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403510 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL3403518 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL3403509 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL3403517 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3297898 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL3403513 | — | IC50 | = | 38.3 | nM | 7.42 |
| CHEMBL3403515 | — | IC50 | = | 42.2 | nM | 7.38 |
| CHEMBL3403512 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL3403514 | — | IC50 | = | 73.2 | nM | 7.13 |
| CHEMBL3403519 | — | IC50 | = | 92.9 | nM | 7.03 |
| CHEMBL3403511 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL3403516 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL553 | ERLOTINIB | IC50 | - | — | - | |
| CHEMBL276711 | SEMAXANIB | IC50 | - | — | - | |
| CHEMBL535 | SUNITINIB | IC50 | - | — | - |