Assay Detail
Functional
CHEMBL3404065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiangiogenic activity in VEGF-165 and bFGF-stimulated chicken embryo chorioallantoic membrane assessed as inhibition of blood vessel formation after 40 hrs by microscopy
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Gallus gallus |
| Tissue | Chorioallantoic membrane |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.69 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.89 |
| CHEMBL3297898 | — | — | 1 | 5.41 |
| CHEMBL3403513 | — | — | 1 | 4.85 |
| CHEMBL3403514 | — | — | 1 | 4.82 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.54 |
| CHEMBL3403510 | — | — | 1 | 4.46 |
| CHEMBL3403512 | — | — | 1 | 4.42 |
| CHEMBL3403515 | — | — | 1 | 4.42 |
| CHEMBL3403518 | — | — | 1 | 4.30 |
| CHEMBL3403509 | — | — | 1 | 4.27 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 4.22 |
| CHEMBL3403511 | — | — | 1 | - |
| CHEMBL3403516 | — | — | 1 | - |
| CHEMBL3403517 | — | — | 1 | - |
| CHEMBL3403519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3297898 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3403513 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3403514 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3403510 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL3403512 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL3403515 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL3403518 | — | IC50 | = | 50100.0 | nM | 4.30 |
| CHEMBL3403509 | — | IC50 | = | 53600.0 | nM | 4.27 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL3403511 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3403516 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3403517 | — | IC50 | = | 104200.0 | nM | - |
| CHEMBL3403519 | — | IC50 | = | 201000.0 | nM | - |