Assay Detail
Functional
CHEMBL3404072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SKOV3 cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.32 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.20 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.16 |
| CHEMBL3403517 | — | — | 1 | 7.89 |
| CHEMBL3403519 | — | — | 1 | 7.61 |
| CHEMBL3297898 | — | — | 1 | 7.43 |
| CHEMBL3403513 | — | — | 1 | 6.92 |
| CHEMBL3403510 | — | — | 1 | 6.89 |
| CHEMBL3403509 | — | — | 1 | 6.43 |
| CHEMBL3403514 | — | — | 1 | 6.37 |
| CHEMBL3403512 | — | — | 1 | - |
| CHEMBL3403511 | — | — | 1 | - |
| CHEMBL3403515 | — | — | 1 | - |
| CHEMBL3403516 | — | — | 1 | - |
| CHEMBL3403518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3403517 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL3403519 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL3297898 | — | IC50 | = | 36.7 | nM | 7.43 |
| CHEMBL3403513 | — | IC50 | = | 120.5 | nM | 6.92 |
| CHEMBL3403510 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL3403509 | — | IC50 | = | 372.3 | nM | 6.43 |
| CHEMBL3403514 | — | IC50 | = | 425.3 | nM | 6.37 |
| CHEMBL3403512 | — | IC50 | - | — | - | |
| CHEMBL3403511 | — | IC50 | - | — | - | |
| CHEMBL3403515 | — | IC50 | - | — | - | |
| CHEMBL3403516 | — | IC50 | - | — | - | |
| CHEMBL3403518 | — | IC50 | - | — | - |