Assay Detail
Functional
CHEMBL3404073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SKOV3-MDR1-M6/6 cells overexpressing wild type beta3 tubulin after 48 hrs by sulforhodamine B assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SKOV3-MDR1-M6/6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.00 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL3403517 | — | — | 1 | 7.71 |
| CHEMBL3403519 | — | — | 1 | 7.51 |
| CHEMBL3297898 | — | — | 1 | 7.20 |
| CHEMBL3403513 | — | — | 1 | 6.81 |
| CHEMBL3403510 | — | — | 1 | 6.69 |
| CHEMBL3403509 | — | — | 1 | 6.32 |
| CHEMBL3403514 | — | — | 1 | 6.29 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.92 |
| CHEMBL3403512 | — | — | 1 | - |
| CHEMBL3403511 | — | — | 1 | - |
| CHEMBL3403515 | — | — | 1 | - |
| CHEMBL3403516 | — | — | 1 | - |
| CHEMBL3403518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3403517 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL3403519 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL3297898 | — | IC50 | = | 63.3 | nM | 7.20 |
| CHEMBL3403513 | — | IC50 | = | 155.2 | nM | 6.81 |
| CHEMBL3403510 | — | IC50 | = | 203.3 | nM | 6.69 |
| CHEMBL3403509 | — | IC50 | = | 482.9 | nM | 6.32 |
| CHEMBL3403514 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1187.2 | nM | 5.92 |
| CHEMBL3403512 | — | IC50 | - | — | - | |
| CHEMBL3403511 | — | IC50 | - | — | - | |
| CHEMBL3403515 | — | IC50 | - | — | - | |
| CHEMBL3403516 | — | IC50 | - | — | - | |
| CHEMBL3403518 | — | IC50 | - | — | - |