Assay Detail
Binding
CHEMBL3404164
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Inhibition of PI3Kalpha (unknown origin) by biochemical Alphascreen assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.80 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403665 | — | — | 1 | 6.38 |
| CHEMBL3403667 | — | — | 1 | 6.21 |
| CHEMBL3403676 | — | — | 1 | 6.08 |
| CHEMBL2216892 | — | — | 1 | 6.05 |
| CHEMBL3403664 | — | — | 1 | 6.04 |
| CHEMBL3403670 | — | — | 1 | 5.97 |
| CHEMBL3403674 | — | — | 1 | 5.94 |
| CHEMBL3403669 | — | — | 1 | 5.92 |
| CHEMBL3403675 | — | — | 1 | 5.92 |
| CHEMBL3403673 | — | — | 1 | 5.86 |
| CHEMBL3403671 | — | — | 1 | 5.80 |
| CHEMBL3403677 | — | — | 1 | 5.36 |
| CHEMBL3403668 | — | — | 1 | 5.29 |
| CHEMBL3403678 | — | — | 1 | 5.10 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 5.01 |
| CHEMBL3403679 | — | — | 1 | - |
| CHEMBL3403666 | — | — | 1 | - |
| CHEMBL3403672 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403665 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3403667 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3403676 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2216892 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3403664 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3403670 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL3403674 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL3403669 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3403675 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3403673 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL3403671 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3403677 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3403668 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL3403678 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3403679 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3403666 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3403672 | — | IC50 | > | 20000.0 | nM | - |