Assay Detail
Binding
CHEMBL3404181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-5-HT from human 5-HT1A receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.58 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350221 | OXITRIPTAN | 3.0 | 1 | 9.04 |
| CHEMBL3401493 | — | — | 1 | 8.99 |
| CHEMBL3401488 | — | — | 1 | 8.98 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.58 |
| CHEMBL3401479 | — | — | 1 | 8.53 |
| CHEMBL3401491 | — | — | 1 | 8.49 |
| CHEMBL574827 | — | — | 1 | 8.28 |
| CHEMBL3401486 | — | — | 1 | 8.20 |
| CHEMBL3401482 | — | — | 1 | 8.13 |
| CHEMBL3401473 | — | — | 1 | 7.82 |
| CHEMBL3401489 | — | — | 1 | 7.79 |
| CHEMBL3401492 | — | — | 1 | 7.58 |
| CHEMBL3401484 | — | — | 1 | 7.54 |
| CHEMBL3401478 | — | — | 1 | 7.44 |
| CHEMBL3401470 | — | — | 1 | 7.43 |
| CHEMBL3401469 | — | — | 1 | 7.40 |
| CHEMBL3401481 | — | — | 1 | 7.36 |
| CHEMBL3401487 | — | — | 1 | 7.29 |
| CHEMBL3401477 | — | — | 1 | 7.27 |
| CHEMBL3401480 | — | — | 1 | 7.12 |
| CHEMBL3401483 | — | — | 1 | 6.94 |
| CHEMBL3401476 | — | — | 1 | 6.94 |
| CHEMBL3401475 | — | — | 1 | 6.83 |
| CHEMBL3401490 | — | — | 1 | 6.68 |
| CHEMBL3401485 | — | — | 1 | 6.57 |
| CHEMBL3401474 | — | — | 1 | 6.44 |
| CHEMBL282199 | — | — | 1 | 5.04 |
| CHEMBL3401472 | — | — | 1 | - |
| CHEMBL3401471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350221 | OXITRIPTAN | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL3401493 | — | Ki | = | 1.03 | nM | 8.99 |
| CHEMBL3401488 | — | Ki | = | 1.04 | nM | 8.98 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 2.65 | nM | 8.58 |
| CHEMBL3401479 | — | Ki | = | 2.96 | nM | 8.53 |
| CHEMBL3401491 | — | Ki | = | 3.23 | nM | 8.49 |
| CHEMBL574827 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL3401486 | — | Ki | = | 6.28 | nM | 8.20 |
| CHEMBL3401482 | — | Ki | = | 7.33 | nM | 8.13 |
| CHEMBL3401473 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL3401489 | — | Ki | = | 16.1 | nM | 7.79 |
| CHEMBL3401492 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL3401484 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL3401478 | — | Ki | = | 36.6 | nM | 7.44 |
| CHEMBL3401470 | — | Ki | = | 37.4 | nM | 7.43 |
| CHEMBL3401469 | — | Ki | = | 39.6 | nM | 7.40 |
| CHEMBL3401481 | — | Ki | = | 43.5 | nM | 7.36 |
| CHEMBL3401487 | — | Ki | = | 51.5 | nM | 7.29 |
| CHEMBL3401477 | — | Ki | = | 53.9 | nM | 7.27 |
| CHEMBL3401480 | — | Ki | = | 75.3 | nM | 7.12 |
| CHEMBL3401483 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL3401476 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL3401475 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL3401490 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL3401485 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL3401474 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL282199 | — | Ki | = | 9024.0 | nM | 5.04 |
| CHEMBL3401472 | — | Ki | - | — | - | |
| CHEMBL3401471 | — | Ki | - | — | - |