Assay Detail
Binding
CHEMBL3404296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of matripase (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins prior to substrate addition by fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Suppressor of tumorigenicity 14 protein (CHEMBL3018) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.22 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 10.70 |
| CHEMBL379586 | — | — | 1 | 8.37 |
| CHEMBL379186 | — | — | 1 | 6.92 |
| CHEMBL3403528 | — | — | 1 | 6.52 |
| CHEMBL3403532 | — | — | 1 | 6.32 |
| CHEMBL3402439 | — | — | 1 | 6.21 |
| CHEMBL3402440 | — | — | 1 | 6.12 |
| CHEMBL3403530 | — | — | 1 | 5.92 |
| CHEMBL3402437 | — | — | 1 | 5.82 |
| CHEMBL356792 | — | — | 1 | 5.75 |
| CHEMBL3403533 | — | — | 1 | 5.60 |
| CHEMBL3403529 | — | — | 1 | 5.58 |
| CHEMBL198362 | RIVAROXABAN | 4.0 | 1 | 5.47 |
| CHEMBL3403531 | — | — | 1 | 5.34 |
| CHEMBL3402438 | — | — | 1 | 5.17 |
| CHEMBL3403521 | — | — | 1 | 5.14 |
| CHEMBL3400827 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL379586 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL379186 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3403528 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3403532 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL3402439 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL3402440 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL3403530 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3402437 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL356792 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3403533 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL3403529 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL198362 | RIVAROXABAN | Ki | = | 3350.0 | nM | 5.47 |
| CHEMBL3403531 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL3402438 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL3403521 | — | Ki | = | 7180.0 | nM | 5.14 |
| CHEMBL3400827 | — | Ki | = | 14900.0 | nM | 4.83 |