Assay Detail
Binding
CHEMBL3404449
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Inhibition of production of human amyloidbeta42 expressed in CHO-2B7 cells after 5 hrs by immunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-2B7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.84 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403819 | — | — | 1 | 7.17 |
| CHEMBL3403826 | — | — | 1 | 7.07 |
| CHEMBL3403825 | — | — | 1 | 7.07 |
| CHEMBL2207069 | — | — | 1 | 7.04 |
| CHEMBL2206994 | — | — | 1 | 7.00 |
| CHEMBL2206993 | — | — | 1 | 7.00 |
| CHEMBL3403816 | — | — | 1 | 6.96 |
| CHEMBL3403822 | — | — | 1 | 6.96 |
| CHEMBL2207050 | — | — | 1 | 6.96 |
| CHEMBL3403817 | — | — | 1 | 6.92 |
| CHEMBL3403827 | — | — | 1 | 6.92 |
| CHEMBL3403820 | — | — | 1 | 6.92 |
| CHEMBL3403818 | — | — | 1 | 6.89 |
| CHEMBL3403815 | — | — | 1 | 6.85 |
| CHEMBL3403824 | — | — | 1 | 6.77 |
| CHEMBL2206995 | — | — | 1 | 6.77 |
| CHEMBL3403823 | — | — | 1 | 6.68 |
| CHEMBL2207043 | — | — | 1 | 6.68 |
| CHEMBL2206986 | — | — | 1 | 6.60 |
| CHEMBL2207042 | — | — | 1 | 6.60 |
| CHEMBL2207044 | — | — | 1 | 6.57 |
| CHEMBL2207065 | — | — | 1 | 6.57 |
| CHEMBL2206992 | — | — | 1 | 6.40 |
| CHEMBL3403821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403819 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3403826 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3403825 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2207069 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2206994 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2206993 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3403816 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3403822 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2207050 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3403817 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3403827 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3403820 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3403818 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3403815 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3403824 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2206995 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3403823 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2207043 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2206986 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2207042 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2207044 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2207065 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2206992 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3403821 | — | IC50 | - | — | - |