Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3404596

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-8-OH-DPAT from human cloned 5-HT1A receptor expressed in HEK293 cells at 0.1 and 1 uM
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fingerprint-based consensus virtual screening towards structurally new 5-HT(6)R ligands.
Smusz S, Kurczab R, Satała G, Bojarski AJ.
Bioorg Med Chem Lett (2015) 25 : 1827 -1830
PubMed 25866241 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 4.93 5.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2011865 1 5.61
CHEMBL1323386 1 5.56
CHEMBL3403338 1 5.42
CHEMBL3403330 1 5.37
CHEMBL3403331 1 5.34
CHEMBL3403335 1 4.99
CHEMBL3403343 1 4.93
CHEMBL1580288 1 4.91
CHEMBL3403340 1 4.90
CHEMBL1319488 1 4.87
CHEMBL3403341 1 4.86
CHEMBL3403337 1 4.81
CHEMBL3403342 1 4.73
CHEMBL3403345 1 4.71
CHEMBL3403344 1 4.70
CHEMBL3403332 1 4.69
CHEMBL3403334 1 4.67
CHEMBL3403333 1 4.63
CHEMBL3403339 1 4.62
CHEMBL1576791 1 4.62
CHEMBL3403336 1 4.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2011865 Ki = 2450.0 nM 5.61
CHEMBL1323386 Ki = 2745.0 nM 5.56
CHEMBL3403338 Ki = 3842.0 nM 5.42
CHEMBL3403330 Ki = 4307.0 nM 5.37
CHEMBL3403331 Ki = 4592.0 nM 5.34
CHEMBL3403335 Ki = 10330.0 nM 4.99
CHEMBL3403343 Ki = 11860.0 nM 4.93
CHEMBL1580288 Ki = 12200.0 nM 4.91
CHEMBL3403340 Ki = 12490.0 nM 4.90
CHEMBL1319488 Ki = 13490.0 nM 4.87
CHEMBL3403341 Ki = 13700.0 nM 4.86
CHEMBL3403337 Ki = 15560.0 nM 4.81
CHEMBL3403342 Ki = 18490.0 nM 4.73
CHEMBL3403345 Ki = 19670.0 nM 4.71
CHEMBL3403344 Ki = 19890.0 nM 4.70
CHEMBL3403332 Ki = 20600.0 nM 4.69
CHEMBL3403334 Ki = 21610.0 nM 4.67
CHEMBL3403333 Ki = 23510.0 nM 4.63
CHEMBL3403339 Ki = 24070.0 nM 4.62
CHEMBL1576791 Ki = 23740.0 nM 4.62
CHEMBL3403336 Ki = 26360.0 nM 4.58