Assay Detail
Binding
CHEMBL3404606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.90 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403346 | — | — | 1 | 7.34 |
| CHEMBL3403373 | — | — | 1 | 6.85 |
| CHEMBL3403372 | — | — | 1 | 6.70 |
| CHEMBL3403360 | — | — | 1 | 6.70 |
| CHEMBL3403371 | — | — | 1 | 6.42 |
| CHEMBL3403361 | — | — | 1 | 6.38 |
| CHEMBL3403365 | — | — | 1 | 6.36 |
| CHEMBL3403358 | — | — | 1 | 6.28 |
| CHEMBL3403359 | — | — | 1 | 6.26 |
| CHEMBL3403367 | — | — | 1 | 6.25 |
| CHEMBL3403362 | — | — | 1 | 5.96 |
| CHEMBL3403369 | — | — | 1 | 5.85 |
| CHEMBL3403366 | — | — | 1 | 5.82 |
| CHEMBL3403368 | — | — | 1 | 5.72 |
| CHEMBL3403370 | — | — | 1 | 5.64 |
| CHEMBL3403353 | — | — | 1 | 5.32 |
| CHEMBL3403349 | — | — | 1 | 4.96 |
| CHEMBL3403354 | — | — | 1 | 4.92 |
| CHEMBL3403363 | — | — | 1 | 4.85 |
| CHEMBL3403355 | — | — | 1 | 4.62 |
| CHEMBL3403364 | — | — | 1 | 4.60 |
| CHEMBL3403347 | — | — | 1 | - |
| CHEMBL3403352 | — | — | 1 | - |
| CHEMBL3403357 | — | — | 1 | - |
| CHEMBL3403351 | — | — | 1 | - |
| CHEMBL3403350 | — | — | 1 | - |
| CHEMBL3403356 | — | — | 1 | - |
| CHEMBL3403348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403346 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3403373 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3403372 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3403360 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3403371 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3403361 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3403365 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3403358 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3403359 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3403367 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3403362 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3403369 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3403366 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3403368 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3403370 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3403353 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3403349 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3403354 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3403363 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3403355 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3403364 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3403347 | — | IC50 | - | — | - | |
| CHEMBL3403352 | — | IC50 | - | — | - | |
| CHEMBL3403357 | — | IC50 | - | — | - | |
| CHEMBL3403351 | — | IC50 | - | — | - | |
| CHEMBL3403350 | — | IC50 | - | — | - | |
| CHEMBL3403356 | — | IC50 | - | — | - | |
| CHEMBL3403348 | — | IC50 | - | — | - |