Assay Detail
Functional
CHEMBL3405076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 8.24 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.80 |
| CHEMBL2417568 | — | — | 1 | 8.97 |
| CHEMBL2419119 | — | — | 1 | 8.94 |
| CHEMBL2419122 | — | — | 1 | 8.91 |
| CHEMBL2419121 | — | — | 1 | 8.76 |
| CHEMBL2419124 | — | — | 1 | 8.58 |
| CHEMBL522201 | — | — | 1 | 8.48 |
| CHEMBL2419116 | — | — | 1 | 8.48 |
| CHEMBL511142 | BUPRENORPHINE | 4.0 | 1 | 8.44 |
| CHEMBL2419118 | — | — | 1 | 8.34 |
| CHEMBL3401556 | — | — | 1 | 8.33 |
| CHEMBL2419123 | — | — | 1 | 8.22 |
| CHEMBL2419125 | — | — | 1 | 8.14 |
| CHEMBL3401558 | — | — | 1 | 7.94 |
| CHEMBL2419120 | — | — | 1 | 7.85 |
| CHEMBL2419117 | — | — | 1 | 7.71 |
| CHEMBL3401554 | — | — | 1 | 7.50 |
| CHEMBL3401555 | — | — | 1 | 7.37 |
| CHEMBL3401557 | — | — | 1 | 7.07 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2417568 | — | EC50 | = | 1.06 | nM | 8.97 |
| CHEMBL2419119 | — | EC50 | = | 1.14 | nM | 8.94 |
| CHEMBL2419122 | — | EC50 | = | 1.23 | nM | 8.91 |
| CHEMBL2419121 | — | EC50 | = | 1.74 | nM | 8.76 |
| CHEMBL2419124 | — | EC50 | = | 2.62 | nM | 8.58 |
| CHEMBL522201 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2419116 | — | EC50 | = | 3.32 | nM | 8.48 |
| CHEMBL511142 | BUPRENORPHINE | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL2419118 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3401556 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2419123 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2419125 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3401558 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2419120 | — | EC50 | = | 14.1 | nM | 7.85 |
| CHEMBL2419117 | — | EC50 | = | 19.4 | nM | 7.71 |
| CHEMBL3401554 | — | EC50 | = | 31.5 | nM | 7.50 |
| CHEMBL3401555 | — | EC50 | = | 42.7 | nM | 7.37 |
| CHEMBL3401557 | — | EC50 | = | 85.2 | nM | 7.07 |
| CHEMBL70 | MORPHINE | EC50 | = | 120.0 | nM | 6.92 |