Assay Detail
Functional
CHEMBL3405097
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Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.47 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.96 |
| CHEMBL3401942 | — | — | 1 | 4.81 |
| CHEMBL3401939 | — | — | 1 | 4.72 |
| CHEMBL3401940 | — | — | 1 | 4.57 |
| CHEMBL3401941 | — | — | 1 | 4.55 |
| CHEMBL3401937 | — | — | 1 | 4.49 |
| CHEMBL3401943 | — | — | 1 | 4.49 |
| CHEMBL3401934 | — | — | 1 | 4.43 |
| CHEMBL3401938 | — | — | 1 | 4.42 |
| CHEMBL3401931 | — | — | 1 | 4.42 |
| CHEMBL3401935 | — | — | 1 | 4.41 |
| CHEMBL3401936 | — | — | 1 | 4.41 |
| CHEMBL3401932 | — | — | 1 | 4.34 |
| CHEMBL3401930 | — | — | 1 | 4.33 |
| CHEMBL3401933 | — | — | 1 | 4.31 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.16 |
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL3401942 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3401939 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL3401940 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL3401941 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL3401937 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL3401943 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL3401934 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL3401938 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL3401931 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL3401935 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL3401936 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL3401932 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3401930 | — | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL3401933 | — | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL7890 | L-NAME | IC50 | = | 69210.0 | nM | 4.16 |
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | IC50 | = | 71300.0 | nM | 4.15 |