Assay Detail
Functional
CHEMBL3405102
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Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.11 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 7.40 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.47 |
| CHEMBL3401941 | — | — | 1 | 4.75 |
| CHEMBL3401939 | — | — | 1 | 4.70 |
| CHEMBL3401942 | — | — | 1 | 4.70 |
| CHEMBL3401940 | — | — | 1 | 4.62 |
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL140 | CURCUMIN | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3401941 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL3401939 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL3401942 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3401940 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | IC50 | = | 71300.0 | nM | 4.15 |