Assay Detail
Binding
CHEMBL3405833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 60 mins by HPLC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Loratadine analogues as MAGL inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.99 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113262 | METHOXYARACHIDONOYL FLUOROPHOSPHONATE | — | 1 | 7.58 |
| CHEMBL3402828 | — | — | 1 | 6.81 |
| CHEMBL3401455 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113262 | METHOXYARACHIDONOYL FLUOROPHOSPHONATE | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL3402828 | — | IC50 | = | 154.88 | nM | 6.81 |
| CHEMBL3401455 | — | IC50 | = | 257.04 | nM | 6.59 |