Assay Detail
Functional
CHEMBL3405930
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum indochina W2 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.46 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | 4.0 | 1 | 8.30 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 8.30 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.15 |
| CHEMBL3401702 | — | — | 1 | 8.10 |
| CHEMBL3401708 | — | — | 1 | 8.00 |
| CHEMBL3401704 | — | — | 1 | 7.92 |
| CHEMBL3401694 | — | — | 1 | 7.85 |
| CHEMBL3401710 | — | — | 1 | 7.85 |
| CHEMBL3403291 | — | — | 1 | 7.82 |
| CHEMBL3403289 | — | — | 1 | 7.82 |
| CHEMBL3400165 | — | — | 1 | 7.72 |
| CHEMBL3401699 | — | — | 1 | 7.72 |
| CHEMBL3401701 | — | — | 1 | 7.62 |
| CHEMBL3401709 | — | — | 1 | 7.60 |
| CHEMBL3401700 | — | — | 1 | 7.58 |
| CHEMBL3401695 | — | — | 1 | 7.52 |
| CHEMBL3401693 | — | — | 1 | 7.51 |
| CHEMBL3401705 | — | — | 1 | 7.48 |
| CHEMBL3401711 | — | — | 1 | 7.44 |
| CHEMBL3403292 | — | — | 1 | 7.42 |
| CHEMBL3401703 | — | — | 1 | 7.42 |
| CHEMBL3403290 | — | — | 1 | 7.41 |
| CHEMBL3401714 | — | — | 1 | 7.32 |
| CHEMBL3401697 | — | — | 1 | 7.16 |
| CHEMBL3401696 | — | — | 1 | 6.98 |
| CHEMBL3401706 | — | — | 1 | 6.79 |
| CHEMBL3401698 | — | — | 1 | 6.76 |
| CHEMBL3401707 | — | — | 1 | 6.64 |
| CHEMBL3401712 | — | — | 1 | 6.62 |
| CHEMBL3401713 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3401702 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3401708 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3401704 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3401694 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3401710 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3403291 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3403289 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3400165 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3401699 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3401701 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3401709 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3401700 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3401695 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3401693 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3401705 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3401711 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3403292 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3401703 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3403290 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3401714 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3401697 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3401696 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3401706 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3401698 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL3401707 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL3401712 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL3401713 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 595.0 | nM | 6.22 |