Assay Detail
Functional
CHEMBL3405932
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Antimalarial activity against multidrug-resistant Plasmodium falciparum thailand TM91C235 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.58 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403289 | — | — | 1 | 8.30 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | 4.0 | 1 | 8.30 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 8.30 |
| CHEMBL3401704 | — | — | 1 | 8.22 |
| CHEMBL3401702 | — | — | 1 | 8.05 |
| CHEMBL3401699 | — | — | 1 | 8.00 |
| CHEMBL3400165 | — | — | 1 | 7.96 |
| CHEMBL3401695 | — | — | 1 | 7.96 |
| CHEMBL3401711 | — | — | 1 | 7.92 |
| CHEMBL3401701 | — | — | 1 | 7.89 |
| CHEMBL3401708 | — | — | 1 | 7.82 |
| CHEMBL3401703 | — | — | 1 | 7.80 |
| CHEMBL3401700 | — | — | 1 | 7.80 |
| CHEMBL3401693 | — | — | 1 | 7.75 |
| CHEMBL3401709 | — | — | 1 | 7.70 |
| CHEMBL3401710 | — | — | 1 | 7.68 |
| CHEMBL3403291 | — | — | 1 | 7.68 |
| CHEMBL3401694 | — | — | 1 | 7.64 |
| CHEMBL3401697 | — | — | 1 | 7.55 |
| CHEMBL3401705 | — | — | 1 | 7.48 |
| CHEMBL3401714 | — | — | 1 | 7.44 |
| CHEMBL3403292 | — | — | 1 | 7.42 |
| CHEMBL3403290 | — | — | 1 | 7.37 |
| CHEMBL3401696 | — | — | 1 | 7.37 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.26 |
| CHEMBL3401698 | — | — | 1 | 7.18 |
| CHEMBL3401706 | — | — | 1 | 6.87 |
| CHEMBL3401712 | — | — | 1 | 6.80 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.69 |
| CHEMBL3401713 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403289 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3401704 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3401702 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3401699 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3400165 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3401695 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3401711 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3401701 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3401708 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3401703 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3401700 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3401693 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3401709 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3401710 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3403291 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3401694 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3401697 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3401705 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3401714 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3403292 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3403290 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3401696 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3401698 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3401706 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL3401712 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL3401713 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3401707 | — | IC50 | = | 456.0 | nM | 6.34 |