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Assay Detail

CHEMBL3406156

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
17
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Publication

Design, synthesis and in vitro cell-based evaluation of the anti-cancer activities of hispolon analogs.
Balaji NV, Ramani MV, Viana AG, Sanglard LP, White J, Mulabagal V, Lee C, Gana TJ, Egiebor NO, Subbaraju GV, Tiwari AK, Tiwari AK.
Bioorg Med Chem (2015) 23 : 2148 -2158
PubMed 25842364 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.67 5.85
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1762214 2 5.85
CHEMBL3402166 1 5.33
CHEMBL452722 HISPOLON 1 5.28
CHEMBL3402168 1 5.28
CHEMBL3402174 1 5.03
CHEMBL3402167 1 4.92
CHEMBL3402170 1 4.65
CHEMBL151608 1 4.48
CHEMBL3402165 1 4.44
CHEMBL3402172 1 4.41
CHEMBL3402171 1 4.38
CHEMBL3402173 1 4.29
CHEMBL356843 1 4.17
CHEMBL481599 1 4.10
CHEMBL1762213 1 4.09
CHEMBL3402169 1 4.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1762214 IC50 = 1400.0 nM 5.85
CHEMBL3402166 IC50 = 4700.0 nM 5.33
CHEMBL3402168 IC50 = 5300.0 nM 5.28
CHEMBL452722 HISPOLON IC50 = 5200.0 nM 5.28
CHEMBL3402174 IC50 = 9400.0 nM 5.03
CHEMBL3402167 IC50 = 11900.0 nM 4.92
CHEMBL3402170 IC50 = 22400.0 nM 4.65
CHEMBL151608 IC50 = 33400.0 nM 4.48
CHEMBL3402165 IC50 = 36500.0 nM 4.44
CHEMBL3402172 IC50 = 38800.0 nM 4.41
CHEMBL3402171 IC50 = 41200.0 nM 4.38
CHEMBL3402173 IC50 = 51300.0 nM 4.29
CHEMBL356843 IC50 = 67900.0 nM 4.17
CHEMBL481599 IC50 = 78800.0 nM 4.10
CHEMBL1762213 IC50 = 80800.0 nM 4.09
CHEMBL3402169 IC50 = 87400.0 nM 4.06
CHEMBL1762214 Activity - -