Assay Detail
Functional
CHEMBL3406362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.63 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3402083 | — | — | 1 | 9.70 |
| CHEMBL3402094 | — | — | 1 | 9.67 |
| CHEMBL3402095 | — | — | 1 | 9.20 |
| CHEMBL3402093 | — | — | 1 | 8.90 |
| CHEMBL3400169 | — | — | 1 | 8.83 |
| CHEMBL3402082 | — | — | 1 | 8.76 |
| CHEMBL3402088 | — | — | 1 | 8.67 |
| CHEMBL3402086 | — | — | 1 | 8.53 |
| CHEMBL3402092 | — | — | 1 | 8.49 |
| CHEMBL3402087 | — | — | 1 | 8.48 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.37 |
| CHEMBL3402084 | — | — | 1 | 8.35 |
| CHEMBL3402085 | — | — | 1 | 8.10 |
| CHEMBL3402091 | — | — | 1 | 8.09 |
| CHEMBL3402090 | — | — | 1 | 8.01 |
| CHEMBL3402089 | — | — | 1 | 7.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3402083 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3402094 | — | IC50 | = | 0.215 | nM | 9.67 |
| CHEMBL3402095 | — | IC50 | = | 0.628 | nM | 9.20 |
| CHEMBL3402093 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL3400169 | — | IC50 | = | 1.47 | nM | 8.83 |
| CHEMBL3402082 | — | IC50 | = | 1.72 | nM | 8.76 |
| CHEMBL3402088 | — | IC50 | = | 2.12 | nM | 8.67 |
| CHEMBL3402086 | — | IC50 | = | 2.95 | nM | 8.53 |
| CHEMBL3402092 | — | IC50 | = | 3.23 | nM | 8.49 |
| CHEMBL3402087 | — | IC50 | = | 3.33 | nM | 8.48 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 4.28 | nM | 8.37 |
| CHEMBL3402084 | — | IC50 | = | 4.46 | nM | 8.35 |
| CHEMBL3402085 | — | IC50 | = | 7.99 | nM | 8.10 |
| CHEMBL3402091 | — | IC50 | = | 8.23 | nM | 8.09 |
| CHEMBL3402090 | — | IC50 | = | 9.74 | nM | 8.01 |
| CHEMBL3402089 | — | IC50 | = | 13.19 | nM | 7.88 |