Assay Detail
Functional
CHEMBL3406372
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Antileishmanial activity against intracellular amastigote stage of Leishmania donovani MHOM/IN/00/DEVI infected in human THP1 cells assessed as decrease infected macrophages after 120 hrs by microscopy
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.94 | 7.22 |
| EC50 | 1 | 5.55 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3400772 | — | — | 1 | 7.22 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.80 |
| CHEMBL57004 | SITAMAQUINE | 2.0 | 1 | 6.00 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 5.55 |
| CHEMBL2441910 | — | — | 1 | 5.26 |
| CHEMBL2042573 | — | — | 1 | 5.19 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.17 |
| CHEMBL3400788 | — | — | 1 | - |
| CHEMBL3400790 | — | — | 1 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
| CHEMBL190951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3400772 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2441910 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2042573 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3400788 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3400790 | — | IC50 | > | 15600.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | IC50 | > | 20000.0 | nM | - |
| CHEMBL190951 | — | IC50 | = | 1220000.0 | nM | - |