Assay Detail
Functional
CHEMBL3406705
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Antimycobacterial activity against Mycobacterium tuberculosis H37Rv expressing Lux assessed as reduction in growth measured after 3 weeks by bioluminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel anti-tuberculosis agents from the celecoxib pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.49 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | 4.0 | 1 | 7.30 |
| CHEMBL3400655 | — | — | 1 | 6.75 |
| CHEMBL3400652 | — | — | 1 | 6.57 |
| CHEMBL3400653 | — | — | 1 | 6.54 |
| CHEMBL3400651 | — | — | 1 | 6.50 |
| CHEMBL64 | ISONIAZID | 4.0 | 1 | 6.48 |
| CHEMBL227875 | PRETOMANID | 4.0 | 1 | 6.40 |
| CHEMBL3400654 | — | — | 1 | 6.37 |
| CHEMBL3400650 | — | — | 1 | 6.32 |
| CHEMBL3400648 | — | — | 1 | 5.66 |
| CHEMBL3298910 | TELACEBEC | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3400655 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3400652 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3400653 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3400651 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL64 | ISONIAZID | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL227875 | PRETOMANID | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3400654 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3400650 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3400648 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3298910 | TELACEBEC | IC50 | < | 3.0 | nM | - |