Assay Detail
Functional
CHEMBL3406899
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Anticancer activity against human EC109 cells assessed as inhibition of proliferation after 72 hrs by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ECa-109 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 1,2,3-triazole-pyrimidine-urea hybrids as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.96 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3401097 | — | — | 1 | 5.60 |
| CHEMBL3401109 | — | — | 1 | 5.53 |
| CHEMBL3401091 | — | — | 1 | 5.27 |
| CHEMBL3401103 | — | — | 1 | 5.23 |
| CHEMBL3401092 | — | — | 1 | 5.17 |
| CHEMBL3401093 | — | — | 1 | 5.14 |
| CHEMBL3400159 | — | — | 1 | 5.13 |
| CHEMBL3401094 | — | — | 1 | 5.13 |
| CHEMBL3401096 | — | — | 1 | 5.13 |
| CHEMBL3401104 | — | — | 1 | 5.11 |
| CHEMBL3401108 | — | — | 1 | 5.10 |
| CHEMBL3401095 | — | — | 1 | 5.05 |
| CHEMBL3401085 | — | — | 1 | 4.95 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.93 |
| CHEMBL3401112 | — | — | 1 | 4.88 |
| CHEMBL3401086 | — | — | 1 | 4.88 |
| CHEMBL3401089 | — | — | 1 | 4.81 |
| CHEMBL3401099 | — | — | 1 | 4.67 |
| CHEMBL3401083 | — | — | 1 | 4.63 |
| CHEMBL3401087 | — | — | 1 | 4.62 |
| CHEMBL3401113 | — | — | 1 | 4.61 |
| CHEMBL3401106 | — | — | 1 | 4.59 |
| CHEMBL3401088 | — | — | 1 | 4.50 |
| CHEMBL3401107 | — | — | 1 | 4.49 |
| CHEMBL3401098 | — | — | 1 | - |
| CHEMBL3401100 | — | — | 1 | - |
| CHEMBL3401101 | — | — | 1 | - |
| CHEMBL3401102 | — | — | 1 | - |
| CHEMBL3401105 | — | — | 1 | - |
| CHEMBL3401090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3401097 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL3401109 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL3401091 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL3401103 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL3401092 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3401093 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL3400159 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL3401094 | — | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL3401096 | — | IC50 | = | 7380.0 | nM | 5.13 |
| CHEMBL3401104 | — | IC50 | = | 7850.0 | nM | 5.11 |
| CHEMBL3401108 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL3401095 | — | IC50 | = | 8960.0 | nM | 5.05 |
| CHEMBL3401085 | — | IC50 | = | 11170.0 | nM | 4.95 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 11610.0 | nM | 4.93 |
| CHEMBL3401086 | — | IC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL3401112 | — | IC50 | = | 13070.0 | nM | 4.88 |
| CHEMBL3401089 | — | IC50 | = | 15510.0 | nM | 4.81 |
| CHEMBL3401099 | — | IC50 | = | 21340.0 | nM | 4.67 |
| CHEMBL3401083 | — | IC50 | = | 23390.0 | nM | 4.63 |
| CHEMBL3401087 | — | IC50 | = | 24220.0 | nM | 4.62 |
| CHEMBL3401113 | — | IC50 | = | 24640.0 | nM | 4.61 |
| CHEMBL3401106 | — | IC50 | = | 25620.0 | nM | 4.59 |
| CHEMBL3401088 | — | IC50 | = | 31310.0 | nM | 4.50 |
| CHEMBL3401107 | — | IC50 | = | 32290.0 | nM | 4.49 |
| CHEMBL3401098 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3401100 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3401101 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3401102 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3401105 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3401090 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3401110 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3401111 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3401084 | — | IC50 | > | 64000.0 | nM | - |