Assay Detail
Binding
CHEMBL3406980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human M3 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.77 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 9.40 |
| CHEMBL3401650 | — | — | 1 | 9.15 |
| CHEMBL3401649 | — | — | 1 | 9.15 |
| CHEMBL3401648 | — | — | 1 | 9.15 |
| CHEMBL3401654 | — | — | 1 | 9.10 |
| CHEMBL3401643 | — | — | 1 | 8.96 |
| CHEMBL1908368 | — | — | 1 | 8.77 |
| CHEMBL3401651 | — | — | 1 | 8.70 |
| CHEMBL3401641 | — | — | 1 | 8.66 |
| CHEMBL3401640 | — | — | 1 | 7.82 |
| CHEMBL3401645 | — | — | 1 | 7.73 |
| CHEMBL3401652 | — | — | 1 | 7.48 |
| CHEMBL3401646 | — | — | 1 | 7.43 |
| CHEMBL3401656 | — | — | 1 | 7.22 |
| CHEMBL3401655 | — | — | 1 | 7.19 |
| CHEMBL3401642 | — | — | 1 | 6.96 |
| CHEMBL3401653 | — | — | 1 | 6.88 |
| CHEMBL3401647 | — | — | 1 | 6.76 |
| CHEMBL3401658 | — | — | 1 | 6.22 |
| CHEMBL3401644 | — | — | 2 | 6.13 |
| CHEMBL3401657 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545181 | TIOTROPIUM BROMIDE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3401650 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3401649 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3401648 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3401654 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3401643 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1908368 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3401651 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3401641 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3401640 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3401645 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL3401652 | — | IC50 | = | 33.4 | nM | 7.48 |
| CHEMBL3401646 | — | IC50 | = | 37.3 | nM | 7.43 |
| CHEMBL3401656 | — | IC50 | = | 60.2 | nM | 7.22 |
| CHEMBL3401655 | — | IC50 | = | 64.4 | nM | 7.19 |
| CHEMBL3401642 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3401653 | — | IC50 | = | 130.5 | nM | 6.88 |
| CHEMBL3401647 | — | IC50 | = | 172.5 | nM | 6.76 |
| CHEMBL3401658 | — | IC50 | = | 599.3 | nM | 6.22 |
| CHEMBL3401644 | — | IC50 | = | 738.6 | nM | 6.13 |
| CHEMBL3401644 | — | IC50 | = | 889.4 | nM | 6.05 |
| CHEMBL3401657 | — | IC50 | = | 1069.4 | nM | 5.97 |