Assay Detail
Binding
CHEMBL3407012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of biotinylated and unactivated BTK (unknown origin) using FITC-labeled Srctide peptide substrate and ATP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
TR-FRET binding assay targeting unactivated form of Bruton's tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.16 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3402355 | — | — | 1 | 9.21 |
| CHEMBL1230541 | — | — | 1 | 9.21 |
| CHEMBL3400826 | — | — | 1 | 8.49 |
| CHEMBL3402353 | — | — | 1 | 8.37 |
| CHEMBL3402356 | — | — | 1 | 8.32 |
| CHEMBL3400825 | — | — | 1 | 8.25 |
| CHEMBL3402354 | — | — | 1 | 8.11 |
| CHEMBL3402357 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3402355 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL1230541 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL3400826 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3402353 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3402356 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3400825 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3402354 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3402357 | — | IC50 | = | 4700.0 | nM | 5.33 |