Assay Detail
Binding
CHEMBL3407013
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Binding affinity to biotinylated and unactivated BTK (unknown origin) incubated for 1 hr by TR-FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
TR-FRET binding assay targeting unactivated form of Bruton's tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.29 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3402355 | — | — | 1 | 8.60 |
| CHEMBL3402356 | — | — | 1 | 8.42 |
| CHEMBL3402353 | — | — | 1 | 8.26 |
| CHEMBL3400825 | — | — | 1 | 8.21 |
| CHEMBL3400826 | — | — | 1 | 8.21 |
| CHEMBL3402354 | — | — | 1 | 8.06 |
| CHEMBL1230541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3402355 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL3402356 | — | Kd | = | 3.8 | nM | 8.42 |
| CHEMBL3402353 | — | Kd | = | 5.5 | nM | 8.26 |
| CHEMBL3400825 | — | Kd | = | 6.1 | nM | 8.21 |
| CHEMBL3400826 | — | Kd | = | 6.2 | nM | 8.21 |
| CHEMBL3402354 | — | Kd | = | 8.8 | nM | 8.06 |
| CHEMBL1230541 | — | Kd | - | — | - |