Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3411253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in transcriptional activity after 24 hrs by CACCC-responsive promoter driven TK-luciferase reporter gene assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HeLa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Krueppel-like factor 10 (CHEMBL3407312)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10): implications for modulation of T regulatory cell differentiation.
Khedkar SA, Sun X, Rigby AC, Feinberg MW.
J Med Chem (2015) 58 : 1466 -1478
PubMed 25581017 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 4.35 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1333704 1 5.00
CHEMBL3410747 1 4.40
CHEMBL2179992 1 4.37
CHEMBL1324 TOLCAPONE 4.0 1 4.30
CHEMBL641 ATOMOXETINE 4.0 1 4.00
CHEMBL3410732 1 4.00
CHEMBL3410741 1 -
CHEMBL3410739 1 -
CHEMBL3410640 1 -
CHEMBL1407890 1 -
CHEMBL3410731 1 -
CHEMBL3410733 1 -
CHEMBL3410734 1 -
CHEMBL3410735 1 -
CHEMBL490514 1 -
CHEMBL3410736 1 -
CHEMBL3410737 1 -
CHEMBL3410738 1 -
CHEMBL1487891 1 -
CHEMBL1350093 1 -
CHEMBL1419342 1 -
CHEMBL592869 1 -
CHEMBL3410749 1 -
CHEMBL3410641 1 -
CHEMBL3410746 1 -
CHEMBL3410745 1 -
CHEMBL3410744 1 -
CHEMBL3410743 1 -
CHEMBL3410742 1 -
CHEMBL3410748 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1333704 IC50 = 10000.0 nM 5.00
CHEMBL3410747 IC50 = 40000.0 nM 4.40
CHEMBL2179992 IC50 = 43000.0 nM 4.37
CHEMBL1324 TOLCAPONE IC50 = 50000.0 nM 4.30
CHEMBL641 ATOMOXETINE IC50 = 100000.0 nM 4.00
CHEMBL3410732 IC50 = 100000.0 nM 4.00
CHEMBL3410640 IC50 - -
CHEMBL3410740 IC50 - -
CHEMBL1407890 IC50 - -
CHEMBL3410731 IC50 - -
CHEMBL3410733 IC50 - -
CHEMBL3410734 IC50 - -
CHEMBL3410735 IC50 - -
CHEMBL490514 IC50 = 200000.0 nM -
CHEMBL3410736 IC50 - -
CHEMBL3410737 IC50 - -
CHEMBL3410738 IC50 - -
CHEMBL3410739 IC50 - -
CHEMBL3410741 IC50 - -
CHEMBL1487891 IC50 - -
CHEMBL1350093 IC50 - -
CHEMBL1419342 IC50 - -
CHEMBL592869 IC50 - -
CHEMBL3410749 IC50 - -
CHEMBL3410641 IC50 = 112000.0 nM -
CHEMBL3410746 IC50 - -
CHEMBL3410745 IC50 - -
CHEMBL3410744 IC50 - -
CHEMBL3410743 IC50 - -
CHEMBL3410742 IC50 - -
CHEMBL3410748 IC50 - -