Assay Detail
Functional
CHEMBL3411271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human BxPC3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of sulfonyl acrylonitriles as novel inhibitors of cancer metastasis and spread.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.46 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410785 | — | — | 1 | 5.51 |
| CHEMBL3410787 | — | — | 1 | 5.51 |
| CHEMBL3410799 | — | — | 1 | 5.47 |
| CHEMBL270299 | BAY-11-7085 | — | 1 | 5.46 |
| CHEMBL3410786 | — | — | 1 | 5.46 |
| CHEMBL3410794 | — | — | 1 | 5.44 |
| CHEMBL3410764 | — | — | 1 | 5.43 |
| CHEMBL3410802 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410785 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3410787 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3410799 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL270299 | BAY-11-7085 | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3410786 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3410794 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3410764 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3410802 | — | EC50 | = | 3800.0 | nM | 5.42 |