Assay Detail
Binding
CHEMBL3411458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human N-terminal His-tagged cIAP1 BIR2-3 C202A/C213G mutant after 60 mins by HTRF assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.24 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410875 | — | — | 1 | 8.54 |
| CHEMBL3410877 | — | — | 1 | 8.47 |
| CHEMBL3410808 | — | — | 1 | 8.47 |
| CHEMBL3410878 | — | — | 1 | 8.44 |
| CHEMBL3410871 | — | — | 1 | 8.40 |
| CHEMBL3410807 | — | — | 1 | 8.38 |
| CHEMBL3410876 | — | — | 1 | 8.35 |
| CHEMBL3410873 | — | — | 1 | 8.33 |
| CHEMBL3410872 | — | — | 1 | 8.32 |
| CHEMBL3410879 | — | — | 1 | 8.31 |
| CHEMBL3410874 | — | — | 1 | 8.25 |
| CHEMBL3339214 | — | — | 1 | 8.00 |
| CHEMBL3410809 | — | — | 1 | 7.77 |
| CHEMBL3039522 | BIRINAPANT | 2.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410875 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3410877 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3410808 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3410878 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3410871 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3410807 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3410876 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3410873 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3410872 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3410879 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3410874 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3339214 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3410809 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3039522 | BIRINAPANT | IC50 | = | 50.0 | nM | 7.30 |