Assay Detail
Binding
CHEMBL3412092
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Inhibition of tubulin (unknown origin) polymerization preincubated for 45 mins followed by GTP addition measured after 2 hrs by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.16 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.44 |
| CHEMBL161957 | SANTIN | — | 1 | 5.24 |
| CHEMBL3407749 | — | — | 1 | 4.75 |
| CHEMBL3407748 | — | — | 1 | 4.71 |
| CHEMBL3407503 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL161957 | SANTIN | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3407749 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL3407748 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL3407503 | — | IC50 | = | 21400.0 | nM | 4.67 |