Assay Detail
Binding
CHEMBL3412296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human GST-thrombin-tagged MDM2 ( 1 to 188 aa) assessed as inhibition of interaction with human p53 preincubated with compound for 20 mins by HTRF assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 9.45 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3407554 | — | — | 1 | 10.00 |
| CHEMBL3125537 | — | — | 1 | 10.00 |
| CHEMBL3407558 | — | — | 1 | 9.89 |
| CHEMBL3236364 | — | — | 1 | 9.77 |
| CHEMBL3407559 | — | — | 1 | 9.74 |
| CHEMBL3407557 | — | — | 1 | 9.74 |
| CHEMBL3407560 | — | — | 1 | 9.68 |
| CHEMBL3407564 | — | — | 1 | 9.68 |
| CHEMBL3407565 | — | — | 1 | 9.68 |
| CHEMBL3407574 | — | — | 1 | 9.59 |
| CHEMBL3407556 | — | — | 1 | 9.43 |
| CHEMBL3407561 | — | — | 1 | 9.43 |
| CHEMBL3407568 | — | — | 1 | 9.38 |
| CHEMBL3407562 | — | — | 1 | 9.31 |
| CHEMBL3407571 | — | — | 1 | 9.31 |
| CHEMBL3407572 | — | — | 1 | 9.28 |
| CHEMBL3125702 | NAVTEMADLIN | 3.0 | 1 | 9.20 |
| CHEMBL3407567 | — | — | 1 | 9.14 |
| CHEMBL3407570 | — | — | 1 | 9.10 |
| CHEMBL3407573 | — | — | 1 | 9.08 |
| CHEMBL3407566 | — | — | 1 | 8.74 |
| CHEMBL3407563 | — | — | 1 | 8.62 |
| CHEMBL3407555 | — | — | 1 | - |
| CHEMBL3407569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3407554 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3125537 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3407558 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3236364 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL3407559 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL3407557 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL3407560 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3407564 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3407565 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3407574 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL3407556 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL3407561 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL3407568 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL3407562 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL3407571 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL3407572 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL3125702 | NAVTEMADLIN | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL3407567 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL3407570 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL3407573 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL3407566 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3407563 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3407555 | — | IC50 | < | 0.1 | nM | - |
| CHEMBL3407569 | — | IC50 | < | 0.1 | nM | - |